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Paramagnetic NMR

Echidna

Echidna: Efficient chi-tensor determination and NH assignment of paramagnetic proteins

The program Echidna has been designed to automatically fit the chi-tensor and assign fully labelled resonances of a 15N-HSQC spectrum in presence of a paramagnetic lanthanide, given a crystal structure and diamagnetic spectrum already assigned.

You can download the program Echidna for academic purpose only. Please, note that this is a scientific code, not necessarily well commented, not necessarily user friendly. Examples used in the publication are available.
You can download the poster of Echidna given at the ComBio 2006 conference in Brisbane.

More details can be found in this publication:

Christophe Schmitz, Michael John, Ah Young Park, Nicholas E. Dixon, Gottfried Otting, Guido Pintacuda and Thomas Huber (2006). Efficient chi-tensor determination and NH assignment of paramagnetic proteins. Journal of Biomolecular NMR. 35:79-87.

Article: [PDF] Supplementary material: [PDF]