Folkers, G.E., Van Der Leede, B.-J.M. and Van Der Saag, P.T. The retinoic acid receptor-ß2 contains two separate cell-specific transactivation domains, at the N-terminus and in the ligand-binding domain. Mol.Endocrinol. 7:616-627, 1993.
Folkers, G.E., Van Heerde, E.C. and Van Der Saag, P.T. Activation function 1 of retinoic acid receptor ß2 is an acidic activator resembling VP16. J.Biol.Chem. 270:23552-23559, 1995.
Folkers, G.E. and Van Der Saag, P.T. Adenovirus E1A functions as a cofactor for retinoic acid receptor ß (RARß) through direct interaction with RARß. Mol.Cell.Biol. 15:5868-5878, 1995.
Folkers, G.E., Van Der Burg,
B. and Van Der Saag, P.T A role for cofactors in synergistic and cell-specific
activation by retinoic acid receptors and retinoid X receptor. J.Steroid
Biochem.Mol.Biol. 56:119-129, 1996.
Co-author papers:
Houwen, F.P., Guangsheng,C., Folkers, G.E., van den Heuvel, W.J.M.G. and Dijkema, C. Pyruvate and fumarate conversion by a metanogenic propionate oxidizing coculture. In: Granular anaerobic sludge: microbiology and thechnology, pp. 62-70, 1988.
Visser, B., Van Der Salm, T., Van Den Brink, W. and Folkers, G. Genes from Bacillus thuringiensis entomocidus 60.5 coding for insect-specific crystal proteins. Mol. Gen. Genet. 212: 219-224, 1988.
Houwen, F.P., Rebers, M., Folkers, G.E., Stams, A.J.M. and Zehnder, A.J.B. The use of a two-liquid-phase electron removal system for culture of proton-reducing bacteria. J. Micr. Meth. 13: 223-230, 1991.
Van Der Leede, B.-J.M., Folkers, G.E., Kruyt, F.A.E. and Van Der Saag, P.T. Genomic organization of the human retinoic acid receptor ß2. Biochem.Biophys.Res.Comm. 188:695-702, 1992.
Kruyt, F.A.E., Folkers, G.E., Van Den Brink, C.E. and Van Der Saag, P.T. A cyclic AMP response element is involved in retinoic acid-dependent RARß2 promoter activation. Nucl.Acids Res. 20:6393-6399, 1992.
Kruyt, F.A.E., Folkers, G.E., Walhout, A.J.M., Van Der Leede, B.-J.M. and Van Der Saag, P.T. E1A functions as a coactivator of retinoic acid-dependent retinoic acid receptor-ß2 promoter activation. Mol.Endocrinol. 7:604-615, 1993.
Pijnappel, W.W.M., Hendriks, H.F.J., Folkers, G.E., Van Den Brink, C.E., Dekker, E.-J., Edelenbosch, C., Van Der Saag, P.T. and Durston, A.J. The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification. Nature 366:340-344, 1993.
Van Der Leede, B.-J.M., Folkers,
G.E., Van Den Brink, C.E., Van Der Saag, P.T. and Van Der Burg, B.
Retinoic acid receptor 1 isoform is induced by estradiol and confers retinoic
acid sensitivity in human breast cancer cells. Mol.Cell.Endocrinol.
109:77-86, 1995.
Submitted or in preparation:
Folkers, G.E., Van Der Burg, B. and Van Der Saag, P.T. Promoter architecture, cofactors and orphan receptors contribute to cell-specific activation of the RAR2 promoter. submitted.
Folkers, G.E., and Van Der Saag, P.T. Different functions for RARs in embryonal carcinoma cell differentiation. submitted.
Folkers, G.E., and Van Der Saag, P.T. Phosphorylation cell-specifically modulates the activity of AF-1 of retinoic acid receptor 2.
Joore, J., Timmermans, A., Van De Water, S., Folkers, G.E., Van Der Saag, P.T., and Zivkovic, D. Domains of retinoid signalling and neuroectodermal expression of Otx1 and Gooscoid are mutually exclusive in the zebrafish gastrula, submitted.
Van der Wees, J., Schilthuis, J.G., Koster, C.H., Diesveld-Schipper, H., Folkers, G.E., Van der Saag, P.T., Dawson, M.I., Shudo, K., Van Der Burg, B., and Durston, A.J. Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain, submitted.
Pijnappel, W.W.M., Folkers, G.E., De Jonge, W.J., Hendriks, H.F.J., Verdegem, P. Lugtenburg, J., De Laat, S.W., Van Der Saag, P.T., and Durston, A.J. Evidence for differenntial agonistic and antagonistic action of a new natural RXR ligand. In preparation.