My Publications

30. Jonker, H.R., Wechselberger, R.W., Pinkse, M., Kaptein, R. and Folkers, G.E. (2006) Gradual phosphorylation regulates PC4 coactivator function. Febs J, 273, 1430-1444. Pubmed

29. Jonker, H.R., Wechselberger, R.W., Boelens, R., Kaptein, R. and Folkers, G.E. (2006) The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions. Biochemistry, 45, 5067-5081. Pubmed

28. de Jong, R.N., Ab, E., Diercks, T., Truffault, V., Daniels, M., Kaptein, R. and Folkers, G.E. (2006) Solution structure of the human ubiquitin-specific protease 15 DUSP domain. J Biol Chem, 281, 5026-5031. Pubmed

27. Tripsianes, K., Folkers, G., Ab, E., Das, D., Odijk, H., Jaspers, N.G., Hoeijmakers, J.H., Kaptein, R. and Boelens, R. (2005) The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair. Structure, 13, 1849-1858. Pubmed

26. Patterson, H.M., Brannigan, J.A., Cutting, S.M., Wilson, K.S., Wilkinson, A.J., Ab, E., Diercks, T., de Jong, R.N., Truffault, V., Folkers, G.E. et al. (2005) The structure of bypass of forespore C, an intercompartmental signaling factor during sporulation in Bacillus. J Biol Chem, 280, 36214-36220. Pubmed

25. Kopke Salinas, R., Folkers, G.E., Bonvin, A.M., Das, D., Boelens, R. and Kaptein, R. (2005) Altered specificity in DNA binding by the lac repressor: a mutant lac headpiece that mimics the gal repressor. Chembiochem, 6, 1628-1637. Pubmed

24.Jonker, H.R., Wechselberger, R.W., Boelens, R., Folkers, G.E. and Kaptein, R. (2005) Structural properties of the promiscuous VP16 activation domain. Biochemistry, 44, 827-839. Pubmed

23. Folkers, G.E., van Buuren, B.N. and Kaptein, R. (2004) Expression screening, protein purification and NMR analysis of human protein domains for structural genomics. J Struct Funct Genomics, 5, 119-131. Pubmed

22. Singh, S., Folkers, G.E., Bonvin, A.M., Boelens, R., Wechselberger, R., Niztayev, A. and Kaptein, R. (2002) Solution structure and DNA-binding properties of the C-terminal domain of UvrC from E.coli. Embo J, 21, 6257-6266. Pubmed

21. Kalodimos, C.G., Folkers, G.E., Boelens, R. and Kaptein, R. (2001) Strong DNA binding by covalently linked dimeric Lac headpiece: evidence for the crucial role of the hinge helices. Proc Natl Acad Sci U S A, 98, 6039-6044. Pubmed

20. Nooren, I.M.A., Folkers, G.E., Kaptein, R., Sauer, R.T. and Boelens, R. (2000) Structure and dynamics of the tetrameric Mnt repressor and a model for its DNA complex. J Biomol Struct Dyn, 113-122. ISI

19. van Tilborg, P.J., Czisch, M., Mulder, F.A., Folkers, G.E., Bonvin, A.M., Nair, M., Boelens, R. and Kaptein, R. (2000) Changes in dynamical behavior of the retinoid X receptor DNA-binding domain upon binding to a 14 base-pair DNA half site. Biochemistry, 39, 8747-8757. Pubmed

18. van Tilborg, P.J., Mulder, F.A., de Backer, M.M., Nair, M., van Heerde, E.C., Folkers, G., van der Saag, P.T., Karimi-Nejad, Y., Boelens, R. and Kaptein, R. (1999) Millisecond to microsecond time scale dynamics of the retinoid X and retinoic acid receptor DNA-binding domains and dimeric complex formation. Biochemistry, 38, 1951-1956. Pubmed

17. van Eijk, M.J., van Rooijen, M.A., Modina, S., Scesi, L., Folkers, G., van Tol, H.T., Bevers, M.M., Fisher, S.R., Lewin, H.A., Rakacolli, D. et al. (1999) Molecular cloning, genetic mapping, and developmental expression of bovine POU5F1. Biol Reprod, 60, 1093-1103 Pubmed.

16. Spronk, C.A., Folkers, G.E., Noordman, A.M., Wechselberger, R., van den Brink, N., Boelens, R. and Kaptein, R. (1999) Hinge-helix formation and DNA bending in various lac repressor-operator complexes. Embo J, 18, 6472-6480. Pubmed.

15. van der Wees, J., Schilthuis, J.G., Koster, C.H., Diesveld-Schipper, H., Folkers, G.E., van der Saag, P.T., Dawson, M.I., Shudo, K., van der Burg, B. and Durston, A.J. (1998) Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain. Development, 125, 545-556. Pubmed

14. Pijnappel, W.W., Folkers, G.E., de Jonge, W.J., Verdegem, P.J., de Laat, S.W., Lugtenburg, J., Hendriks, H.F., van der Saag, P.T. and Durston, A.J. (1998) Metabolism to a response pathway selective retinoid ligand during axial pattern formation. Proc Natl Acad Sci U S A, 95, 15424-15429. Pubmed

13.Folkers, G.E., van der Burg, B. and van der Saag, P.T. (1998) Promoter architecture, cofactors, and orphan receptors contribute to cell-specific activation of the retinoic acid receptor beta2 promoter. J Biol Chem, 273, 32200-32212. Pubmed

12. Joore, J., Timmermans, A., van de Water, S., Folkers, G.E., van der Saag, P.T. and Zivkovic, D. (1997) Domains of retinoid signalling and neurectodermal expression of zebrafish otx1 and goosecoid are mutually exclusive. Biochem Cell Biol, 75, 601-612 Pubmed.

11. Folkers, G.E., Van der Burg, B. and Van der Saag, P.T. (1996) A role for cofactors in synergistic and cell-specific activation by retinoic acid receptors and retinoid X receptor. J Steroid Biochem Mol Biol, 56, 119-129. Pubmed

10. van der Leede, B.J., Folkers, G.E., van den Brink, C.E., van der Saag, P.T. and van der Burg, B. (1995) Retinoic acid receptor alpha 1 isoform is induced by estradiol and confers retinoic acid sensitivity in human breast cancer cells. Mol Cell Endocrinol, 109, 77-86. Pubmed

9. Folkers, G.E., van Heerde, E.C. and van der Saag, P.T. (1995) Activation function 1 of retinoic acid receptor beta 2 is an acidic activator resembling VP16. J Biol Chem, 270, 23552-23559. Pubmed

8. Folkers, G.E. and van der Saag, P.T. (1995) Adenovirus E1A functions as a cofactor for retinoic acid receptor beta (RAR beta) through direct interaction with RAR beta. Mol Cell Biol, 15, 5868-5878. Pubmed

7. Pijnappel, W.W., Hendriks, H.F., Folkers, G.E., van den Brink, C.E., Dekker, E.J., Edelenbosch, C., van der Saag, P.T. and Durston, A.J. (1993) The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification. Nature, 366, 340-344. Pubmed

6. Kruyt, F.A., Folkers, G.E., Walhout, A.J., van der Leede, B.J. and van der Saag, P.T. (1993) E1A functions as a coactivator of retinoic acid-dependent retinoic acid receptor-beta 2 promoter activation. Mol Endocrinol, 7, 604-615. Pubmed

5. Folkers, G.E., van der Leede, B.J. and van der Saag, P.T. (1993) The retinoic acid receptor-beta 2 contains two separate cell-specific transactivation domains, at the N-terminus and in the ligand-binding domain. Mol Endocrinol, 7, 616-627. Pubmed

4. van der Leede, B.J., Folkers, G.E., Kruyt, F.A. and van der Saag, P.T. (1992) Genomic organization of the human retinoic acid receptor beta 2. Biochem Biophys Res Commun, 188, 695-702. Pubmed

3.Kruyt, F.A., Folkers, G., van den Brink, C.E. and van der Saag, P.T. (1992) A cyclic AMP response element is involved in retinoic acid-dependent RAR beta 2 promoter activation. Nucleic Acids Res, 20, 6393-6399.Pubmed

2. Houwen, F.P., Rebers, M., Folkers, G.E., Stams, A.J.M. and Zehnder, A.J.B. (1991) The Use of a 2-Liquid-Phase Electron Removal System for Culture of Proton-Reducing Bacteria. J Microbiol Meth, 13, 223-230. ISI

1. Visser, B., Vandersalm, T., Vandenbrink, W. and Folkers, G. (1988) Genes from Bacillus Thuringiensis-Entomocidus 60.5 Coding for Insect-Specific Crystal Proteins. Mol Gen Genet, 212, 219-224.ISI